To test whether the EVAC can be applied to transgastrically accessible infected cavities.
Single-center case study.
Academic medical center.
Two patients with necrotizing pancreatitis.
Successful closure of leak.
We successfully applied EVAC to treat transgastrically accessible necrotic cavities.
Small case number.
EVAC might be an important additional endoscopic treatment option for infected pancreatic necrosis, especially if established endoscopic treatment options fail.