Low High Density Lipoprotein Cholesterol: Prevalence and Associated Risk-Factors in a Large French Population

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• 作者：Marion Rouvre MD^a ; Sylviane Vol MSc^b ; Gaë ; lle Gusto PhD^b ; Catherine Born MD^b ; Olivier Lantieri MD ; MPH^b ; Jean Tichet MD^b ; Pierre Lecomte MD^a ; ^{lecomte@med.univ-tours.fr}
• 关键词：HDL Cholesterol ; Reference Values ; Psychosocial Deprivation ; Risk Factors ; Epidemiologic Study ; Risk Reduction Behavior
• 刊名：Annals of Epidemiology
• 出版年：2011
• 出版时间：February 2011
• 年：2011
• 卷：21
• 期：2
• 页码：118-127
• 全文大小：281 K

文摘

Purpose

High density lipoprotein-cholesterol (HDL-C) is a strong predictor of cardiovascular risk. We investigated the distribution of HDL-C in a French general population according to age, sex, and the risk factors associated with low HDL-C values.

Methods

A group of 18,483 men and 22,047 women 16–79 years of age were investigated during a medical check-up. Relevant parameters were studied in three groups according to age and gender-specific percentile classes (≤5th [HDL₅] median and >95th). Gender-specific logistic regression models selected variables associated with HDL₅.

Results

Using the National Cholesterol Education Program Adult Treatment Panel III criteria (threshold: 40 mg/dL in men, 50 mg/dL in women) the prevalence of low HDL-C was 11.1 % and 26.4 % in men and women and it decreased with age. Mean HDL-C levels increased with age. HDL₅ was positively associated with a sedentary lifestyle and deprivation (p < 0.00001) even after adjustment on alcohol consumption and smoking. Abdominal obesity, smoking, hypertriglyceridemia, hyperleucocytosis, and low alcohol consumption were associated with HDL₅ for both genders.

Conclusions

The prevalence of low HDL-C was similar to that observed in other Europeans but lower than in the United States. HDL₅ was associated with cardiovascular risk factors, metabolic syndrome, and social deprivation. A prevention policy to increase HDL-C levels should focus on reducing smoking and abdominal obesity, particularly in deprived subjects.