刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:29 January 2017
年:2017
卷:483
期:1
页码:680-686
全文大小:1369 K
卷排序:483
文摘
Pharmacologic quinones elicit distinct compartmentalized oxidation of glutathione poise. Cytosolic oxidation is NQO1-dependent whereas mitochondrial is cell line dependent. High DNQ potency is result of its outstanding NQO1 substrate specificity. Low DNQ concentrations required for solid cancer treatments mitigate off target effects. β-lapachone at pharmacologic doses triggers oxidation of cysteines in normal cells.