- 作者：R. Zamora-Ros ; M. Serafini ; R. Estruch ; R.M. Lamuela-Ravent贸s ; M.A. Mart铆nez-Gonz谩lez ; J. Salas-Salvad贸 ; M. Fiol ; J. Lapetra ; F. Ar贸s ; M.I. Covas ; C. Andres-Lacueva ; on behalf of the PREDIMED Study Investigators
- 关键词：Non enzymatic antioxidant capacity ; Total antioxidant capacity ; Dietary modulation ; Oxidative stress ; PREDIMED
- 刊名：Nutrition, Metabolism and Cardiovascular Diseases
- 出版年：December, 2013
- 年：2013
- 卷：23
- 期：12
- 页码：1167-1174
- 全文大小：474 K
Background and aims
The intake of antioxidant-rich foods may increase the blood levels of non enzymatic antioxidant capacity (NEAC). NEAC takes into account all antioxidants from food and synergistic effects between them. We examined the effect of a 1-year intervention with Mediterranean diet on plasma NEAC and assessed whether it was related to baseline NEAC levels.Methods and results
Five hundred sixty-four participants at high cardiovascular risk were randomly selected from the PREDIMED (Prevenci贸n con DIeta MEDiterr谩nea) Study, a large 3-arm randomized clinical trial. Blood NEAC levels were measured at baseline and after 1-year of dietary intervention with 1) a Mediterranean diet supplemented with virgin olive oil (MED聽+聽VOO); 2) a Mediterranean diet supplemented with nuts (MED聽+聽nuts), or 3) a control low-fat diet. Plasma NEAC was analyzed using FRAP (ferric reducing antioxidant potential) and TRAP (total radical-trapping antioxidant parameter) assays. Plasma FRAP levels increased after 1-year of intervention with MED聽+聽VOO [72.0聽渭mol/L (95% CI, 34.2-109.9)] and MED聽+聽nuts [48.9聽渭mol/L (24.3-73.5)], but not after the control low-fat diet [13.9聽渭mol/L (鈭?1.9 to 39.8)]. Participants in the lowest quartile of plasma FRAP at baseline significantly increased their levels after any intervention, while those in the highest quartile decreased. Similar results occurred with TRAP levels.
Conclusions
This study shows that a 1-year of MED diet intervention increases plasma TAC level in subjects at high risk for cardiovascular disease. Moreover, the effectiveness of dietary supplementation with antioxidants may be related to baseline levels of plasma NEAC.