Thymic involution and proliferative T-cell responses in multiple sclerosis

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• 作者：Danielle A. Duszczyszyn ; Julia L. Williams ; Helen Mason ; Yves Lapierre ; Jack Antel ; David G. Haegert
• 关键词：T-cells ; MS ; Neuroimmunology ; T-cell receptors ; Homeostasis
• 刊名：Journal of Neuroimmunology
• 出版年：2010
• 出版时间：15 April 2010
• 年：2010
• 卷：221
• 期：1-2
• 页码：73-80
• 全文大小：883 K

文摘

We investigated naïve CD4 T-cell homeostasis in relapsing–remitting multiple sclerosis (RRMS). Quantification of signal joint T-cell receptor excision circles in FACS-isolated CD31hi cells, which correspond closely to CD4 recent thymic emigrants (RTEs), indicates that young patients have reduced generation of CD4 RTEs compared to age-matched controls. In RRMS, compared to controls, CXCR4 analyses indicate age-associated thymic output of progressively immature CD4 RTEs, and Ki-67 data demonstrate altered T-cell proliferative responses that fail to maintain naïve CD4 T-cell numbers with age. Thus, RRMS patients have early thymic involution with compensatory homeostatic peripheral T-cell proliferative responses that may predispose patients to autoreactivity.