Bone marrow-derived macrophages and the CNS: An update on the use of experimental chimeric mouse models and bone marrow transplantation in neurological disorders
详细信息 查看全文
- 作者：Antoine Larochelle ; Marc-André ; Bellavance ; Jean-Philippe Michaud ; Serge Rivest ; Serge.Rivest@crchudequebec.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bone marrow ; Myeloid cells ; Chimeric mice ; Alzheimer's disease ; Stroke ; Multiple sclerosis
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：1862
- 期：3
- 页码：310-322
- 全文大小：1223 K
文摘
- •
The use of myeloablation and bone marrow transplantation allowed the generation of chimeric mice to study the role resident microglia and infiltrated bone marrow-derived macrophages (BMDM) separately in the brain.
- •
We here review the advent of this methodology and compare the different strategies used to perform myeloablation.
- •
We discuss the roles of microglia and BMDM in neurological disorders.