Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands
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- 作者：Marie Laronze-Cochard ; Young-Min Kim ; Bertr ; Brassart ; Jean-Franç ; ois Riou ; Jean-Yves Laronze ; Janos Sapi
- 关键词：Telomere ; G-quadruplex ligand ; 4 ; 5-Disubstituted acridine
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2009
- 出版时间：October 2009
- 年：2009
- 卷：44
- 期：10
- 页码：3880-3888
- 全文大小：424 K
文摘
Several 4,5-bis(dialkylaminoalkyl)-substituted acridines have been prepared starting from acridine and their telomeric G-quadruplex stabilizing properties were evaluated using FRET melting and TRAP (Telomerase Repeat Amplification Protocol Assay) experiments.