Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs
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- 作者：Roman Galeev1 ; Auré ; lie Baudet1 ; Praveen Kumar1 ; Alexandra Rundberg Nilsson2 ; Bjö ; rn Nilsson4 ; Shamit Soneji2 ; Therese Tö ; rngren3 ; Å ; ke Borg3 ; Anders Kvist3 ; Jonas Larsson1 ; jonas.larsson@med.lu.se" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：29 March 2016
- 年：2016
- 卷：14
- 期：12
- 页码：2988-3000
- 全文大小：2801 K
文摘
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A genome-wide RNAi screen was performed in primary human CD34+ cells
Several cohesin genes were identified as modifiers of renewal and differentiation
Cohesin-deficient HSCs show enhanced reconstitution capacity in vivo
Cohesin deficiency induces immediate HSC-specific transcriptional programs