Regional specific modulation of neuronal activation associated with nitric oxide synthase inhibitors in an animal model of antidepressant activity
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- 作者：Eoin Sherwina ; c ; Valentina Gigliuccib ; c ; Andrew Harkinb ; c ; aharkin@tcd.ie" class="auth_mail" title="E-mail the corresponding author
- 关键词：Stress ; Forced swimming test ; 5-HT ; nNOS ; c-FOS ; ΔFosB
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：18-28
- 全文大小：2986 K
文摘
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NOS inhibitors reduce immobility time and increase FST-induced c-FOS immunoreactivity in the lateral septum.
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NOS inhibitors reduce FST-induced c-FOS immunoreactivity in the dorsal dentate gyrus, ventral CA1 and dorsal raphe nucleus.
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Treatment with pCPA and restraint stress provokes a reduction in delta FosB in the lateral septum.
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pCPA and restraint stress provoke an increase in delta FosB in the infra-limbic cortex and nucleus accumbens.
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Regional changes in the expression of delta FosB relate to increased immobility in the FST.