P2Y receptor specific for diadenosine tetraphosphate in lung: selective inhibition by suramin, PPADS, Ip₅I, and not by MRS-2197

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• 作者：Laubinger ; Werner ; Wang ; Hong ; Welte ; Tobias ; Reiser ; Georg
• 关键词：Ca²⁺ mobilization ; Diadenosine polyphosphate ; Diinosine pentaphosphate ; Evans blue ; G protein-coupled receptor ; MRS-2197 ; P2 receptor ; PPADS ; Reactive blue 2 ; Suramin
• 刊名：European Journal of Pharmacology
• 出版年：2003
• 出版时间：May 2, 2003
• 年：2003
• 卷：468
• 期：1
• 页码：9-14
• 全文大小：177 K

文摘

Extracellular dinucleotides, which act as signaling molecules in a variety of systems, may regulate fluid homeostasis in the human lung by activation of a specific P2Y receptor subtype. Previously, we presented evidence for a G protein-coupled P2Y receptor with high affinity for dinucleotides in both rat and human lung tissue. In a human bronchial epithelial cell line (HBE-1), diadenosine polyphosphates (Ap_nA, n