Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In聽Vivo
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- 作者：Petter S. Woll1 ; Una Kjä ; llquist2 ; Onima Chowdhury1 ; Helen Doolittle1 ; David C. Wedge3 ; Supat Thongjuea1 ; Rikard Erlandsson2 ; Mtakai Ngara4 ; Kristina Anderson5 ; Qiaolin Deng4 ; Adam J. Mead1 ; Laura Stenson1 ; Alice Giustacchini1 ; Sara Duarte1 ; Eleni Giannoulatou6 ; Stephen Taylor6 ; Mohsen Karimi7 ; Christian Scharenberg7 ; Teresa Mortera-Blanco7 ; Iain C. Macaulay1 ; Sally-Ann Clark1 ; Ingunn Dybedal8 ; Dag Josefsen5 ; Pierre Fenaux9 ; Peter Hokland10 ; Mette S. Holm10 ; Mario Cazzola11 ; Luca Malcovati11 ; Sudhir Tauro12 ; David Bowen13 ; Jacqueline Boultwood14 ; Andrea Pellagatti14 ; John E. Pimanda15 ; Ashwin Unnikrishnan15 ; Paresh Vyas16 ; 17 ; Gudrun Gö ; hring18 ; Brigitte Schlegelberger18 ; Magnus Tobiasson7 ; Gunnar Kvalheim5 ; Stefan N. Constantinescu19 ; Claus Nerlov16 ; Lars Nilsson20 ; Peter J. Campbell3 ; Rickard Sandberg4 ; Elli Papaemmanuil3 ; Eva Hellströ ; m-Lindberg7 ; Sten Linnarsson2 ; Sten Eirik W. Jacobsen1 ; 21 ; sten.jacobsen@imm.ox.ac.uk" class="auth_mail
- 刊名：Cancer Cell
- 出版年：16 June 2014
- 年：2014
- 卷：25
- 期：6
- 页码：794-808
- 全文大小：5360 K
文摘
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MDS stem cells and progenitors are distinct and hierarchically related
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Mutations in low-risk MDS originate exclusively in distinct and rare MDS stem cells
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Mutations preceding AML transformation might confer self-renewal to MDS progenitors
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del(5q) precedes acquisition of recurrent driver mutations in isolated del(5q) MDS