RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription
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- 作者：Laura Baranello1 ; 9 ; Damian Wojtowicz2 ; 9 ; Kairong Cui3 ; Ballachanda N. Devaiah4 ; Hye-Jung Chung1 ; Ka Yim Chan-Salis5 ; Rajarshi Guha6 ; Kelli Wilson6 ; Xiaohu Zhang6 ; Hongliang Zhang7 ; Jason Piotrowski8 ; Craig J. Thomas6 ; Dinah S. Singer4 ; B. Franklin Pugh5 ; Yves Pommier7 ; Teresa M. Przytycka2 ; Fedor Kouzine1 ; 10 ; Brian A. Lewis8 ; 10 ; Keji Zhao3 ; 10 ; zhaok@nhlbi.nih.gov" class="auth_mail" title="E-mail the corresponding author ; David Levens1 ; 10 ; levens@helix.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：7 April 2016
- 年：2016
- 卷：165
- 期：2
- 页码：357-371
- 全文大小：4297 K
文摘
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The DNA relaxation of TOP1 is coordinated with pause-release
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TOP1 activity is stimulated by BRD4-dependent phosphorylation of RNAPII
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The N-term domain of TOP1 mediates interaction and stimulation by RNAPII
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BRD4 inhibitors and TOP1 inhibitors synergize in killing cells