Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia

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• 作者：Tom&#xe1 ; s Meroñ ; o ; Patricia Sorroche ; Leonardo A. Gó ; mez Rosso ; Liliana Casañ ; as ; Laura E. Boero ; Jorge A. Arbelbide ; Fern ; o D. Brites
• 关键词：Iron ; Iron deficiency anaemia ; Atherosclerosis ; Cholesteryl ester transfer protein ; Paraoxonase 1 ; Lipoprotein-associated phospholipase A₂ ; Oxidized LDL
• 刊名：Clinical Biochemistry
• 出版年：2010
• 出版时间：March 2010
• 年：2010
• 卷：43
• 期：4-5
• 页码：416-423
• 全文大小：301 K

文摘

Objective

To characterize the lipid-related atherogenic risk factors in iron deficiency anaemia (IDA) patients.

Design and methods

Twenty IDA women were compared to healthy age-matched controls. Lipoprotein profile, cholesteryl ester transfer protein (CETP), paraoxonase (PON) 1 and lipoprotein-associated phospholipase A₂ (LpPLA₂) activities and plasma levels of oxidized-LDL were evaluated.

Results

Triglycerides were higher (median [range]) (1.0 [0.5–1.9] vs. 0.7 [0.5–1.5] mmol/L, p < 0.05) and HDL-C lower (mean ± SD) (1.3 ± 0.3 vs. 1.6 ± 0.4 mmol/L, p < 0.01) in the patients group. CETP (197 ± 29 % vs. 151 ± 29 % mL^− 1 h^− 1, p < 0.001), PON 1 (122 ± 17 vs. 140 ± 33 μmol mL^− 1 min^− 1, p < 0.05) and LpPLA₂ (9.6 ± 2.0 vs. 8.1 ± 1.7 μmol mL^− 1 h^− 1, p < 0.05) activities were different in IDA women. No difference was observed in oxidized-LDL. Haemoglobin correlated negatively with triglycerides (r = − 0.35, p < 0.05), CETP (r =  −  0.62, p < 0.001) and LpPLA₂ (r =  −  0.34, p < 0.05), while ferritin was positively associated with HDL-C (r =  0.39, p < 0.05) and inversely with CETP (r =  −  0.49, p < 0.005).

Conclusion

The alterations in lipoprotein profile, CETP, PON 1 and LpPLA₂ activities described in the present study indicate that non-treated IDA might represent a proatherogenic state.