DISC1 signaling in cocaine addiction: Towards molecular mechanisms of co-morbidity
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- 作者：Amy Gancarzb ; Yan Jouroukhina ; Atsushi Saitoa ; Alexey Shevelkina ; Lauren E. Muellerb ; Atsushi Kamiyaa ; David M. Dietzb ; ddietz@buffalo.edu" class="auth_mail" title="E-mail the corresponding author ; Mikhail V. Pletnikova ; c ; d ; e ; mpletni1@jhu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cocaine ; DISC1 ; Co-morbidity ; Drug abuse ; Psychiatric disorders
- 刊名：Neuroscience Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：105
- 期：Complete
- 页码：70-74
- 全文大小：638 K
文摘
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Cocaine self-administration up-regulates DISC1 expression in the nucleus accumbens.
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DISC1 knockdown in the nucleus accumbens increases cocaine self-administration.
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DISC1 knockdown in the nucleus accumbens decreases GSK-3β phosphorylation.
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Substance abuse and other psychiatric disorders may share molecular pathology.