Dopamine Regulation of Lateral Inhibition between Striatal Neurons Gates the Stimulant Actions of Cocaine
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- 作者：Lauren K. Dobbs1 ; Alanna R. Kaplan1 ; Julia C. Lemos1 ; Aya Matsui1 ; Marcelo Rubinstein2 ; 3 ; 4 ; Veronica A. Alvarez1 ; alvarezva@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：90
- 期：5
- 页码：1100-1113
- 全文大小：3707 K
文摘
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Synchronized activation of GABA transmission from multiple iMSNs inhibits APs in dMSNs
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Cocaine suppresses lateral inhibition via D2Rs in iMSNs to disinhibit dMSNs
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D2R agonist show higher efficacy at axon collaterals than at projections to VP
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D2Rs in iMSNs are required for the stimulant effect of cocaine on locomotion