Methods for studying human organogenesis

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• 作者：Gerald Cunha ; ^{gerald.cunha@ucsf.edu" class="auth_mail" title="E-mail the corresponding author} ; Maya Overland ; Yi Li ; Mei Cao ; Joel Shen ; Adriane Sinclair ; Laurence Baskin
• 关键词：Human development ; Male and female external genitalia ; Internal genitalia
• 刊名：Differentiation
• 出版年：2016
• 出版时间：April-June 2016
• 年：2016
• 卷：91
• 期：4-5
• 页码：10-14
• 全文大小：1358 K

文摘

This review details methods for utilizing D & C suction abortus specimens as a source of human fetal organs to study the morphogenetic and molecular mechanisms of human fetal organ development. By this means it is possible to design experiments elucidating the molecular mechanisms of human fetal organ development and to compare and contrast human developmental mechanisms with that of laboratory animals. Finally human fetal organs can be grown in vivo as grafts to athymic mice, thus allowing ethical analysis of potential adverse effects of environmental toxicants.