A Degrading View of Regulatory T?Cells

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• 作者：Arian Laurence ; Yasmine Belkaid ; John?J. O¡¯Shea
• 刊名：Immunity
• 出版年：2013
• 出版时间：22 August, 2013
• 年：2013
• 卷：39
• 期：2
• 页码：201-203
• 全文大小：199 K

文摘

Studies by van Loosdregt et?al. and Chen et?al. in this issue of Immunity provide evidence for previously unrecognized players that regulate FOXP3 degradation. These are interesting developments that point to unappreciated mechanisms by which inflammatory signals can impact expression of FOXP3 and possibly the stability of Treg cell phenotypes.