Effects of hepatocellular iron imbalance on nitric oxide and reactive oxygen intermediates production in a model of sepsis
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- 作者：Jung ; Martin ; Drapier ; Jean-Claude ; Weidenbach ; Hans ; Renia ; Laurent ; Oliveira ; Leonor ; Wang ; Aiguo ; et. al.
- 关键词：Iron ; Liver failure ; Oxidative damage ; Radicals ; Sepsis
- 刊名：Journal of Hepatology
- 出版年：2000
- 出版时间：September, 2000
- 年：2000
- 卷：33
- 期：3
- 页码：387-394
- 全文大小：1.04 M
文摘
Background/Aims: In mammals iron homeostasis is most important, as imbalance of iron such as iron overload may lead to severe diseases. Recently, it has been shown that the iron regulatory protein-1 is partially controlled by nitric oxide and reactive oxygen intermediates, molecules frequently seen in inflammatory events. The aim of the present study was to investigate the effects of impaired iron homeostasis on the interaction of nitric oxide, and reactive oxygen intermediate formation in hepatocytes in a model of acute inflammation.