eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition
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- 作者：Angelita Simonetti1 ; a.simonetti@ibmc-cnrs.unistra.fr" class="auth_mail" title="E-mail the corresponding author ; Jailson Brito Querido1 ; Alexander G. Myasnikov2 ; Eder Mancera-Martinez1 ; Adeline Renaud1 ; Lauriane Kuhn3 ; Yaser Hashem1 ; y.hashem@ibmc-cnrs.unistra.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：eukaryotic translation initiation ; ribosome ; eIF3 ; eIF3 peripheral subunits ; cryo-EM
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：21 July 2016
- 年：2016
- 卷：63
- 期：2
- 页码：206-217
- 全文大小：7107 K
文摘
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Several subunits of eIF3 relocate upon mRNA binding and start-codon recognition
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mRNA binding leads to the relocation of eIF3b to interact with eIF2 ternary complex
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eIF3i+g relocate to the 40S intersubunit face after start-codon recognition
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eIF3b and eIF1 reposition the eIF2 ternary complex and assist in scanning