Neuropsychiatric characteristics of GBA-associated Parkinson disease
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- 作者：Matthew Swan ; MDa ; b ; 1 ; matthew.c.swan@gmail.com" class="auth_mail" title="E-mail the corresponding author ; matswan@montefiore.org" class="auth_mail" title="E-mail the corresponding author ; Nancy Doana ; 2 ; Robert A. Ortega ; MSa ; 2 ; Matthew Barrett ; MDc ; 3 ; MJB5T@hscmail.mcc.virginia.edu" class="auth_mail" title="E-mail the corresponding author ; William Nichols ; PhDd ; 4 ; bill.nichols@cchmc.org" class="auth_mail" title="E-mail the corresponding author ; Laurie Ozelius ; PhDe ; 5 ; lozelius@partners.org" class="auth_mail" title="E-mail the corresponding author ; Jeannie Soto-Valencia ; BAa ; 2 ; Sarah Boschung ; BSNa ; 2 ; Andres Deik ; MDa ; Andres.DeikAcostaMadiedo@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author ; Harini Sarva ; MDa ; sarvaharini@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jose Cabassa ; MDa ; jose.c.cabassa@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Brooke Johannes ; MSc ; MS ; CGCa ; 2 ; Deborah Raymond ; MS ; CGCa ; 2 ; Karen Marder ; MD ; MPHf ; 6 ; ksm1@columbia.edu" class="auth_mail" title="E-mail the corresponding author ; Nir Giladi ; MDg ; nirg@tlvmc.gov.il" class="auth_mail" title="E-mail the corresponding author ; Joan Miravite ; FNPa ; 2 ; William Severt ; MD ; PhDa ; 2 ; Rivka Sachdev ; MDa ; 2 ; Vicki Shanker ; MDa ; 2 ; Susan Bressman ; MDa ; 2 ; Rachel Saunders-Pullman ; MD ; MPHa ; 2 ; RSaunder@chpnet.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parkinson disease ; Glucocerebrosidase ; GBA1 ; Depression ; Anxiety
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：370
- 期：Complete
- 页码：63-69
- 全文大小：330 K
文摘
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GBA1 mutations confer greater susceptibility to depression in those with Parkinson disease (PD).
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This relationship persists when controlled for age, sex, disease duration, motor disability, and cognitive performance.
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Men with PD due to GBA1 mutations may experience greater anxiety and depression than men with PD without GBA1 mutations.