Combined major element and Sr–Nd trace element and isotopic ratios AFC modelling suggest that the Parxed;cutin series resulted from the evolution of an initial basaltic andesite (compositionally similar to some olivine-hosted melt inclusions) in a magma reservoir located at ~ 10–15 km depth. The AFC model supports a continuous process involving the assimilation of up to ~ 35–40 % granite-derived melts (with 87Sr/86Sr = 0.7085 and 143Nd/144Nd = 0.511928) by the initial magma, which crystallized ~ 15 % of a mineral assemblage mainly constituted by plagioclase (restricted to the earliest stages) and orthopyroxene, and minor olivine and clinopyroxene, within a temperature range of ~ 1220 °C–1100 °C. Such high assimilation rates can be explained if the thermal state of the lithosphere was already favourable for melt production at the time of emplacement of the andesitic magma. Under such conditions, crustal assimilation could develop as a syn-eruptive process that allows to explain the relatively higher volumes of less differentiated lavas extruded by the Parxed;cutin volcano as a consequence of its waning activity with time.