A facile intramolecular azido/amido reductive cyclization approach: synthesis of pyrrolobenzodiazepines and their dimers

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• 作者：Ahmed Kamal ; N. Shankaraiah ; N. Mark ; eya ; K. Laxma Reddy ; Ch. Sanjeeva Reddy
• 关键词：Pyrrolo[2 ; 1-c][1 ; 4]benzodiazepines ; Intramolecular reductive cyclization ; Azides ; Amides ; LiAlH₄ ; LiBH₄
• 刊名：Tetrahedron Letters
• 出版年：2008
• 出版时间：25 February 2008
• 年：2008
• 卷：49
• 期：9
• 页码：1465-1468
• 全文大小：127 K

文摘

A new synthetic pathway has been developed for the preparation of imine-containing pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) and their dimers. Selective reduction of aromatic azides as well as aliphatic amides in a single step leading to an intramolecular reductive cyclization process by employing LiAlH₄ or LiBH₄ provides the cyclized imines.