Blessure et?r¡§|paration ¡§|pith¡§|liale : une?hypoth¡§¡§se physiopathologique de?la?polypose nasosinusienne
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- 作者：Diane S. Lazard<sup>1sup><sup> ; sup><sup>2sup><sup> ; sup><sup>dianelazard@yahoo.frsup> ; Virginie Pruliè ; re-Escabasse<sup>1sup><sup> ; sup><sup>3sup> ; Jean-Franç ; ois Papon<sup>1sup><sup> ; sup><sup>3sup> ; Estelle Escudier<sup>1sup><sup> ; sup><sup>4sup> ; André ; Coste<sup>1sup><sup> ; sup><sup>3sup>
- 刊名：La Presse M¡§|dicale
- 出版年：2007
- 出版时间：July¡§CAugust 2007
- 年：2007
- 卷：36
- 期：7-8
- 页码：1104-1108
- 全文大小：631 K
文摘
| Figures/TablesFigures/Tables | ReferencesReferencession=""1.0"" encoding=""UTF-8""?>
ss=""h3"">Key points
<strong class=""boldFont"">Nasal polyposis (NP), asthma, and chronic bronchitisstrong> are chronic inflammatory diseases of the upper airways.<strong class=""boldFont"">They may be caused by injury to the respiratory epitheliumstrong> in a chronic inflammatory environment.
<strong class=""boldFont"">Several studies show that during NP nasal epithelial cellsstrong> are involved in the overexpression of cytokines and growth factors.
<strong class=""boldFont"">Among these, transforming growth factor |1 (TGF-|1)strong> appears to play a major role in the genesis of NP.
<strong class=""boldFont"">Differentiated respiratory epithelium,strong> obtained from in vivo or in vitro models, is used to study wound healing in inflammatory environments, to elucidate the pathophysiology of NP, and to improve understanding and management of upper airway inflammatory diseases.