Initial development of a multigene ‘omics-based exposure biomarker for pyrethroid pesticides
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- 作者：Adam D. Biales<sup> ; sup><sup>abiales@hotmail.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Mitchell S. Kostich ; Angela L. Batt ; Mary J. See ; Robert W. Flick ; Denise A. Gordon ; Jim M. Lazorchak ; David C. Bencic
- 关键词：Pyrethroids ; Gene expression ; Microarray ; Fish ; Aquatic
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：179
- 期：Complete
- 页码：27-35
- 全文大小：561 K
文摘
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Need for a systematic process of developing omics based tools.
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Developed a multi-gene expression-based biomarker for pyrethroid pesticides.
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Biomarker was able to identify fish exposed to ng/L levels of any of four pyrethroids.
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Introduce a method to minimize the effects of inter-experiment variability on tool performance.