Acute anti-allodynic action of gabapentin in dorsal horn and primary somatosensory cortex: Correlation of behavioural and physiological data

详细信息    查看全文

• 作者：Sascha R.A. Alles^a ; ¹ ; Mischa V. Bandet^a ; Kate Eppler^d ; Myung-Chul Noh^d ; Ian R. Winship^a ; ^b ; Glen Baker^a ; ^b ; Klaus Ballanyi^a ; ^c ; Peter A. Smith^a ; ^d ; ^{pas3@ualberta.ca}
• 关键词：Neuropathic pain ; Electrophysiology ; In vivo calcium imaging ; Alpha 2 delta ; Substantia gelatinosa ; Synaptic transmission
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：576-590
• 全文大小：2842 K
• 卷排序：113

文摘

Gabapentin (GBP) relieves neuropathic pain in animal models within 30 min. Spinal cord slices obtained ex vivo from GBP-treated rats have reduced excitability. Synaptic drive to excitatory substantia gelatinosa neurons is decreased. GBP actions in vivo are mediated intracellularly. GBP affects the neurotransmitter release machinery in vivo.