Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation
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- 作者：Namir Shaabania ; b ; 1 ; Vishal Khairnara ; 1 ; Vikas Duhana ; 1 ; Fan Zhoua ; Rita Ferrer Tura ; Dieter Hä ; ussingerb ; Mike Recherc ; Alexei V. Tumanovd ; Cornelia Hardta ; Daniel Pinschewere ; Urs Christenf ; Philipp A. Langb ; g ; 1 ; Nadine Honkea ; b ; 1 ; Karl S. Langa ; b ; 1 ; karlsebastian.lang@uk-essen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Immunopathology ; Lymphocytic choriomeningitis virus (LCMV) ; Enforced viral replication
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：67
- 期：Complete
- 页码：82-89
- 全文大小：1700 K
文摘
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Viral replication is essential for activation of CD8+ T cells.
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Viral distribution along marginal zone is necessary for systemic induction of IFN-I.
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Viral replication is Usp18 dependent while viral distribution is LT dependent