Intrahepatic regulation of antiviral T cell responses at initial stages of viral infection
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- 作者：Yuejin Liang ; yu2liang@utmb.edu" class="auth_mail" title="E-mail the corresponding author ; Zakari Kwota ; Jiaren Sun
- 关键词：Ad ; adenovirus ; APCs ; antigen-presenting cells ; CTL ; cytotoxic T lymphocyte ; DAMP ; damage associated molecule pattern ; DCs ; dendritic cells ; Gal-9 ; galectin-9 ; γδ T ; gamma delta T ; HSCs ; hepatic stellate cells ; iNKT ; invariant NKT ; IFNs ; interferons ; IFN-I ; type I interferon ; ILCs ; innate lymphoid cells ; KCs ; Kupffer cells ; LCMV ; lymphocytic choriomeningitis virus ; LSECs ; liver sinusoidal endothelial cells ; LSECtin ; liver sinusoidal endothelial cell lectin ; MHV ; mouse hepatitis virus ; NK ; natura
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：39
- 期：Complete
- 页码：106-112
- 全文大小：354 K
文摘
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Liver resident cells play both antigen-presenting functions and immune-inhibitory effects in viral heaptitis.
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Liver kupffer cells are weak antigen presenting cells and induce CD8 T cell exhaustion through IL-10 and PD/1PD-L1 pathway.
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Type 2 and 3 innate lymphoid cells play the different roles in regulating antiviral T cell response in the liver.