T Cell Factor 1-Expressing Memory-like CD8+ T Cells Sustain the Immune Response to Chronic Viral Infections
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- 作者：Daniel T. Utzschneider1 ; 7 ; 9 ; Mé ; lanie Charmoy2 ; 7 ; Vijaykumar Chennupati2 ; 7 ; Laurè ; ne Pousse2 ; 7 ; Daniela Pais Ferreira2 ; Sandra Calderon-Copete3 ; Maxime Danilo2 ; Francesca Alfei1 ; 10 ; Maike Hofmann4 ; Dominik Wieland4 ; 5 ; 6 ; Sylvain Pradervand3 ; Robert Thimme4 ; Dietmar Zehn1 ; 8 ; 10 ; dietmar.zehn@tum.de" class="auth_mail" title="E-mail the corresponding author ; Werner Held2 ; 8 ; werner.held@unil.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：chronic infection ; differentiation of cytotoxic T cells ; T cell exhaustion ; T cell memory ; Tcf1 ; LCMV ; PD-1
- 刊名：Immunity
- 出版年：2016
- 出版时间：16 August 2016
- 年：2016
- 卷：45
- 期：2
- 页码：415-427
- 全文大小：3330 K
文摘
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Virus-specific Tcf1+CD8+ T cells sustain the immune response to chronic infection
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These cells have traits of central memory and exhausted but not of effector cells
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They retain proliferative capacity, regenerate, and produce differentiated cells
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They are critical for the proliferative response to inhibitory receptor blockade