The effect of n-3 LCPUFA supplementation on oxidative stress and inflammation in the placenta and maternal plasma during pregnancy
详细信息 查看全文
- 作者：G.E. Leghia ; B.S. Muhlhauslera ; b ; beverly.muhlhausler@adelaide.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：CYP450 ; cytochrome P450 ; JZ ; junctional zone ; LPS ; lipopolysaccharide ; LZ ; labyrinth zone ; OS ; oxidative stress ; ROS ; reactive oxygen species ; RNS ; reactive nitrogen species
- 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：113
- 期：Complete
- 页码：33-39
- 全文大小：394 K
文摘
- •
N-3 LCPUFA can reduce placental oxidative stress at low/moderate doses, but increase oxidative stress at high doses.
- •
The preterm placenta is more sensitive to oxidative damage by n-3 LCPUFA.
- •
N-3 LCPUFA increase placental resolvin and protectin concentrations.
- •
N-3 LCPUFA can decrease levels of maternal pro-inflammatory mediators.
- •
30">Further studies are needed to resolve issues around the most effective dose and timing of n-3 LCPUFA intervention.