APBB1 reinforces cancer stem cell and epithelial-to-mesenchymal transition by regulating the IGF1R signaling pathway in non-small-cell lung cancer cells

详细信息    查看全文

• 作者：Jei Ha Lee^a ; ^b ; Jung Yul Kim^a ; ^b ; Seo Yeon Kim^a ; Soo Im Choi^a ; Kuk Chan Kim^a ; Eun Wie Cho^c ; In Gyu Kim^a ; ^b ; ^{igkim@kaeri.re.kr}
• 关键词：ALDH1 ; APBB1 ; Cancer stem cell ; EMT ; IGF1R
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：482
• 期：1
• 页码：35-42
• 全文大小：1968 K
• 卷排序：482

文摘

APBB1 was highly expressed in ALDH1high cells sorted from A549 cells. APBB1 is associated with intensifying CSC and EMT and enhancing radiation-resistant properties of lung cancer cells. APBB1 regulates EMT-associated CSC-like properties and γ-radiation resistance via activation of IGF1Rβ/AKT/GSK3β pathway. APBB1 partly regulates the expression of ALDH1 via AKT/GSK3β-associated β-catenin pathway.