Human brain atlas for automated region of interest selection in quantitative susceptibility mapping: Application to determine iron content in deep gray matter structures

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• 作者：Issel Anne L. Lim ; Andreia V. Faria ; Xu Li ; Johnny T.C. Hsu ; Raag D. Airan ; Susumu Mori ; Peter C.M. van Zijl
• 关键词：AIR ; Automated Image Registration ; Amg ; Amygdala ; CC ; Corpus Callosum ; CCb ; Body of the Corpus Callosum ; CCg ; Genu of the Corpus Callosum ; CCs ; Splenium of the Corpus Callosum ; CN ; Caudate Nucleus ; CSF ; Cerebrospinal Fluid ; COSMOS ; Calculation of Suscepti
• 刊名：NeuroImage
• 出版年：2013
• 出版时间：15 November, 2013
• 年：2013
• 卷：82
• 期：Complete
• 页码：449-469
• 全文大小：3664 K

文摘

The purpose of this paper is to extend the single-subject Eve atlas from Johns Hopkins University, which currently contains diffusion tensor and T₁-weighted anatomical maps, by including contrast based on quantitative susceptibility mapping. The new atlas combines a ¡°deep gray matter parcellation map¡± (DGMPM) derived from a single-subject quantitative susceptibility map with the previously established ¡°white matter parcellation map¡± (WMPM) from the same subject's T₁-weighted and diffusion tensor imaging data into an MNI coordinate map named the ¡°Everything Parcellation Map in Eve Space,¡± also known as the ¡°EvePM.¡± It allows automated segmentation of gray matter and white matter structures. Quantitative susceptibility maps from five healthy male volunteers (30 to 33 years of age) were coregistered to the Eve Atlas with AIR and Large Deformation Diffeomorphic Metric Mapping (LDDMM), and the transformation matrices were applied to the EvePM to produce automated parcellation in subject space. Parcellation accuracy was measured with a kappa analysis for the left and right structures of six deep gray matter regions. For multi-orientation QSM images, the Kappa statistic was 0.85 between automated and manual segmentation, with the inter-rater reproducibility Kappa being 0.89 for the human raters, suggesting ¡°almost perfect¡± agreement between all segmentation methods. Segmentation seemed slightly more difficult for human raters on single-orientation QSM images, with the Kappa statistic being 0.88 between automated and manual segmentation, and 0.85 and 0.86 between human raters. Overall, this atlas provides a time-efficient tool for automated coregistration and segmentation of quantitative susceptibility data to analyze many regions of interest. These data were used to establish a baseline for normal magnetic susceptibility measurements for over 60 brain structures of 30- to 33-year-old males. Correlating the average susceptibility with age-based iron concentrations in gray matter structures measured by allowed interpolation of the average iron concentration of several deep gray matter regions delineated in the EvePM.