Synthetic organic compounds with potential for bacterial biofilm inhibition, a path for the identification of compounds interfering with quorum sensing

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• 作者：Andr茅a de Lima Pimenta ; Louise Domeneghini Chiaradia-Delatorre ; Aless ; ra Mascarello ; Karen Andrin茅ia de Oliveira ; Paulo C茅sar Leal ; Rosendo Augusto Yunes ; Cl谩udia Beatriz Nedel Mendes de Aguiar ; Carla In锚s Tasca ; Ricado Jos茅 Nunes ; Artur Sm芒nia Jr.
• 关键词：Biofilm ; Quorum sensing ; Biofilm inhibitors ; Antimicrobial therapy ; Synthetic compounds
• 刊名：International Journal of Antimicrobial Agents
• 出版年：December, 2013
• 年：2013
• 卷：42
• 期：6
• 页码：519-523
• 全文大小：203 K

文摘

New unconventional approaches to the development of antimicrobial drugs must target inhibition of infection stages leading to host colonisation or virulence itself, rather than bacterial viability. Amongst the most promising unconventional targets for the development of new antimicrobial drugs is bacterial adherence and biofilm formation as well as their control system, the quorum-sensing (QS) system, a mechanism of communication used to co-ordinate bacterial activities. Here we describe the evaluation of synthetic organic compounds as bacterial biofilm inhibitors against a panel of clinically relevant Gram-positive and Gram-negative bacterial strains. This approach has successfully allowed the identification of five compounds (GEt, GHex, GOctad, G19 and C33) active not only against bacterial biofilms but also displaying potential to be used as antagonists and/or inhibitors of bacterial QS.