Effect of lipid composition and amino acid sequence upon transmembrane peptide-accelerated lipid transleaflet diffusion (flip-flop)
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- 作者：Jamie LeBarron ; Erwin London
- 关键词：Vesicles ; Flip-flop ; Transmembrane peptide ; Lipid asymmetry ; Transverse diffusion ; Bilayer width
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1858
- 期：8
- 页码：1812-1820
- 全文大小：982 K
文摘
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Peptides accelerate lipid flip across the bilayer in a sequence-dependent fashion.
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An Asp in the core of the hydrophobic sequence accelerates flip.
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Flip is accelerated by peptides in both transmembrane and non-transmembrane states.
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Cholesterol and very long acyl lipid chains inhibit peptide-accelerated flip.
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Membrane thinning may explain peptide-accelerated flip.