Three novel B-type mannose-specific lectins of Cynoglossus semilaevis possess varied antibacterial activities against Gram-negative and Gram-positive bacteria
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- 作者：Yuan-yuan Suna ; b ; d ; 1 ; Li Liua ; b ; d ; 1 ; Jun Lic ; Li Suna ; b ; lsun@qdio.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：B-type lectin ; Cynoglossus semilaevis ; Agglutination ; Antibacterial
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：55
- 期：Complete
- 页码：194-202
- 全文大小：2833 K
文摘
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CsBML1, CsBML2, and CsBML3 possess three conserved mannose binding sites.
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The expression of all three lectins was upregulated by bacterial infection.
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Recombinant lectins bound to a wide arrange of bacteria with different affinities.
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All three lectins had mannose-specific and Ca2+-dependent agglutinating capacities.
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rCsBML1 and rCsBML2 are bactericidal and inhibited bacterial infection in vivo.