A comprehensive database of published tDCS clinical trials (2005-2016)

详细信息    查看全文

• 作者：Jean-Pascal Lefaucheur^a ; ^b ; ^{jean-pascal.lefaucheur@hmn.aphp.fr}
• 关键词：Brain stimulation ; Cortex ; Neurology ; Neurostimulation ; Psychiatry ; Study design ; Treatment
• 刊名：Neurophysiologie Clinique/Clinical Neurophysiology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：46
• 期：6
• 页码：319-398
• 全文大小：4148 K
• 卷排序：46

文摘

Transcranial direct current stimulation (tDCS) is a technique of noninvasive cortical stimulation allowing significant modification of brain functions. Clinical application of this technique was reported for the first time in March 2005. This paper presents a detailed list of the 340 articles (excluding single case reports) which have assessed the clinical effect of tDCS in patients, at least when delivered to cortical targets. The reviewed conditions were: pain syndromes, Parkinson's disease, dystonia, cerebral palsy, post-stroke limb motor impairment, post-stroke neglect, post-stroke dysphagia, post-stroke aphasia, primary progressive aphasia, multiple sclerosis, epilepsy, consciousness disorders, Alzheimer's disease and other types of dementia, tinnitus, depression, auditory hallucinations and negative symptoms of schizophrenia, addiction and craving, autism, and attention disorders. The following data were collected: (i) clinical condition; (ii) study design; (iii) sample size; (iv) anode and cathode locations; (v) stimulation intensity and electrode area; (vi) number and duration of sessions; (vii) clinical outcome measures and results. This article does not include any meta-analysis and aims simply at providing a comprehensive overview of the raw data reported in this field to date, as an aid to researchers.