NADPH oxidase 4 contributes to connective tissue growth factor expression through Smad3-dependent signaling pathway
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- 作者：Xin-Hua Liua ; Qiu-Yan Zhanga ; Li-Long Pana ; Si-Yu Liua ; Peng Xua ; Xiao-Ling Luoa ; Si-Li Zoub ; Hong Xina ; Le-Feng Qub ; qulefengsubmit@163.com" class="auth_mail" title="E-mail the corresponding author ; Yi-Zhun Zhua ; c ; zhuyz@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：CTGF ; connective tissue growth factor ; DPI ; diphenylene iodonium ; Nox4 ; NADPH oxidase 4 ; ROS ; Reactive oxygen species ; TGF-β ; transforming growth factor-β ; VSMC ; vascular smooth muscle cells
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：94
- 期：Complete
- 页码：174-184
- 全文大小：2724 K
文摘
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Upregulation of Nox4 and CTGF expression in the atherosclerosis.
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Smad3-dependent pathway mediates TGF-β1-induced CTGF expression.
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Nox4 and Smad3 are responsible for TGF-β1-evoked CTGF expression.
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Nox4 modulates TGF-β1-mediated Smad3 signaling activation.