A novel one-pot synthesis of N,6-disubstituted 1,3,5-triazine-4,6-diamines from isothiocyanates and amidines
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- 作者：Chunjian Liu ; James Lin ; Katerina Leftheris
- 刊名：Tetrahedron Letters
- 出版年：2007
- 出版时间：15 January 2007
- 年：2007
- 卷：48
- 期：3
- 页码：435-437
- 全文大小：114 K
文摘
A novel one-pot procedure for the preparation of N,6-disubstituted-1,3,5-triazine-2,4-diamines and its scope of application are demonstrated with a number of examples. The new procedure involves the treatment of isothiocyanates with sodium hydrogencyanamide, followed by amidines in the presence of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride.