Cerebral peritumoral oedema study: Does a single dynamic MR sequence assessing perfusion and permeability can help to differentiate glioblastoma from metastasis?

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• 作者：Pierre Lehmann^a ; ^d ; ^g ; ^{pierre.lehmann@ah-hm.fr} ; Guillaume Saliou^c ; Giovanni de Marco^b ; Pauline Monet^a ; Stoquart-Elsankari Souraya^e ; Alexis Bruniau^f ; Jean Noel Vallé ; e^a ; Denis Ducreux^c
• 关键词：MR ; Perfusion ; Permeability ; Glioblastoma ; Metastasis
• 刊名：European Journal of Radiology
• 出版年：2012
• 出版时间：March 2012
• 年：2012
• 卷：81
• 期：3
• 页码：522-527
• 全文大小：884 K

文摘

Our purpose was to differentiate glioblastoma from metastasis using a single dynamic MR sequence to assess perfusion and permeability parameters. 24 patients with glioblastoma or cerebral metastasis with peritumoral oedema were recruited and explored with a 3 T MR unit. Post processing used DPTools software. Regions of interest were drawn around contrast enhancement to assess relative cerebral blood volume and permeability parameters. Around the contrast enhancement Glioblastoma present high rCBV with modification of the permeability, metastasis present slight modified rCBV without modification of permeability. In conclusion, peritumoral T2 hypersignal exploration associating morphological MR and functional MR parameters can help to differentiate cerebral metastasis from glioblastoma.