Inhibition of glutathione production by L-S,R-buthionine sulfoximine activates hepatic ascorbate synthesis - A unique anti-oxidative stress mechanism in mice
刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:26 February 2017
年:2017
卷:484
期:1
页码:56-63
全文大小:1596 K
卷排序:484
文摘
Inhibition of GSH production causes a high toxicity to guinea pigs, but not to mice. Inhibition of GSH production increased mouse tissue ascorbate levels. Induction of ascorbate synthesis prevents mice from oxidative stress injury. Guinea pigs have reduced capacity of protecting against oxidative stress than mice.