Association between the Absolute Baseline Lymphocyte Count and Response to Neoadjuvant Platinum-based Chemotherapy in Muscle-invasive Bladder Cancer
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- 作者：R. Leibowitz-Amit&lowast ; ; &dagger ; &dagger ; ; A. Israel&dagger ; ; M. Gal&lowast ; ; E.A. Atenafu&Dagger ; ; Z. Symon&lowast ; ; &dagger ; &dagger ; ; O. Portnoy§ ; ; &dagger ; &dagger ; ; M. Laufer¶ ; ; Z. Dotan¶ ; ; &dagger ; &dagger ; ; J. Ramon¶ ; ; &dagger ; &dagger ; ; D. Avni|| ; E. Fridman&lowast ; &lowast ; ; &dagger ; &dagger ; ; R. Berger&lowast ; ; &dagger ; &dagger ; ; raanan.berger@sheba.health.gov.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bladder cancer ; chemosensitivity ; lymphocytes ; MIBC ; neoadjuvant chemotherapy ; urothelial carcinoma
- 刊名：Clinical Oncology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：28
- 期：12
- 页码：790-796
- 全文大小：987 K
文摘
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There are no biomarkers of response to neoadjuvant chemotherapy in muscle invasive bladder cancer.
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Achievement of pathological complete response (pCR) at radical cystectomy is associated with improved survival.
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A higher pre-chemotherapy lymphocyte count was associated with pCR.
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Responders had higher lymphocyte counts than non-responders throughout treatment and recovery.
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Our results suggest that the adaptive immune arm may affect chemosensitivity.