The Role of Endometrial Biopsy in the Preoperative Detection of Uterine Leiomyosarcoma

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• 作者：Emily M. Hinchcliff ; MD^a ; ^b ; ^c ; ^{ehinchcliff@partners.org" class="auth_mail" title="E-mail the corresponding author} ; Katharine M. Esselen ; MD ; MBA^a ; ^c ; Jaclyn C. Watkins ; MD^a ; ^c ; ^d ; Titilope Oduyebo ; MD^a ; ^b ; ^c ; J. Alejandro Rauh-Hain ; MD^b ; ^c ; Marcela G. del Carmen ; MD^b ; ^c ; Bradley J. Quade ; MD ; PhD^a ; ^c ; ^d ; Michael G. Muto ; MD^a ; ^c
• 关键词：Uterine leiomyoma ; Uterine leiomyosarcoma ; Endometrial biopsy
• 刊名：Journal of Minimally Invasive Gynecology
• 出版年：2016
• 出版时间：May-June 2016
• 年：2016
• 卷：23
• 期：4
• 页码：567-572
• 全文大小：327 K

文摘

To assess the sensitivity of preoperative endometrial biopsy in detection of uterine leiomyosarcoma (ULMS).

Study Design

Retrospective analysis of a prospectively collected database (Canadian Task Force III).

Setting

Two academic tertiary referral centers.

Patients

All cases of ULMS treated at participating institutions between January 2005 and August 2012 were identified following IRB approval.

Interventions

Abstracted data included demographics, preoperative evaluation, presenting symptom, surgical management, pathology and clinical outcomes. Chi-square tests were used for statistical analysis.

Measurements and Main Results

329 cases were identified, of which 152 cases had complete pathologic data available for review. Sixty-eight (45%) of 152 patients had endometrial sampling prior to surgery. Patients with postmenopausal bleeding were significantly more likely to be biopsied preoperatively (51.6% vs 9.5%, p = <.0001). Of those sampled, 43 (63%) underwent endometrial pipelle biopsies and 25 (37%) had dilation and curettage. Endometrial sampling was significantly more likely to detect a concern for malignancy in patients who presented with postmenopausal bleeding (72.7% vs 32.3%, p = 0.002), however it was less likely to detect malignancy in patients with abnormal premenopausal bleeding (31.8% vs 64.3%, p = .02), compared to other presenting symptoms. Overall, 51.5% of patients with ULMS on final pathology had preoperative endometrial biopsies in which leiomyosarcoma or atypical spindle cell proliferation were diagnosed, whereas 35.5% of the pre-operative biopsies identified ULMS specifically.

Conclusions

The sensitivity of an endometrial biopsy to detect ULMS is low, illustrating the difficulty of diagnosing ULMS preoperatively. As expected, the probability that an endometrial biopsy will detect ULMS or a related worrisome pathological finding is higher for patients with post-menopausal bleeding. Thus, benign endometrial biopsy results, particularly in pre-menopausal patients, should be interpreted with caution if there is suspicion for leiomyosarcoma. However, a positive or suspicious result can play an important role in the subsequent management of patients with ULMS, even if the absolute numbers of affected patients are small.