Development of large-scale functional networks over the lifespan

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• 作者：Winfried Schlee ; Vera Leirer ; Stephan Kolassa ; Franka Thurm ; Thomas Elbert ; Iris-Tatjana Kolassa
• 关键词：Functional networks ; Lifespan ; MEG ; Cognitive decline
• 刊名：Neurobiology of Aging
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：33
• 期：10
• 页码：2411-2421
• 全文大小：1363 K

文摘

The development of large-scale functional organization of the human brain across the lifespan is not well understood. Here we used magnetoencephalographic recordings of 53 adults (ages 18-89) to characterize functional brain networks in the resting state. Slow frequencies engage larger networks than higher frequencies and show different development over the lifespan. Networks in the delta (2-4 Hz) frequency range decrease, while networks in the beta/gamma frequency range (> 16 Hz) increase in size with advancing age. Results show that the right frontal lobe and the temporal areas in both hemispheres are important relay stations in the expanding high-frequency networks. Neuropsychological tests confirmed the tendency of cognitive decline with older age. The decrease in visual memory and visuoconstructive functions was strongly associated with the age-dependent enhancement of functional connectivity in both temporal lobes. Using functional network analysis this study elucidates important neuronal principles underlying age-related cognitive decline paving mental deterioration in senescence.