In vitro activity of synthetic tetrahydroindeno[2,1-c]quinolines on Leishmania mexicana
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- 作者：Concepció ; n Herná ; ndez-Chineaa ; hernandezchinea@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Erika Carbajoa ; Felipe Sojob ; Francisco Arvelob ; c ; Vladimir V. Kouznetsovd ; Arnold R. Romero-Bohó ; rquezd ; Pedro J. Romeroa
- 关键词：Leishmania mexicana ; Promastigote ; Indenoquinoline ; Antileishmanial drugs
- 刊名：Parasitology International
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：64
- 期：6
- 页码：479-483
- 全文大小：686 K
文摘
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Antileishmanial activity of synthetic tetrahydroindeno [2,1-c]quinolines was evaluated in vitro.
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Compounds were active against promastigotes of Leishmania mexicana.
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Two of the most active compounds (1 and 3) impair amastigote survival in macrophages.
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Results indicate that compound 3 is the best candidate for development of antileishmanial drugs.