In vivo HMRS and lipidomic profiling reveals comprehensive changes of hippocampal metabolism during aging in mice
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- 作者：Lejun Lina ; 1 ; Bofeng Caob ; 1 ; Zhiying Xua ; easy0603@163.com" class="auth_mail" title="E-mail the corresponding author ; Yanbin Suib ; Jiao Chenb ; Qiang Luanc ; Ruifang Yangd ; Shanchun Lia ; Ke Feng Lie ; kefengl@sunnypeak.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Brain aging ; Hippocampus ; Metabolic interactions ; 9.4T HMRS ; Lipidomics
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：29 January 2016
- 年：2016
- 卷：470
- 期：1
- 页码：9-14
- 全文大小：1427 K
文摘
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A footprint of comprehensive metabolic aging in mice hippocampus was provided.
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Neurotransmitters, sphingolipids, and phosphatidylinositols decrease with aging.
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Hippocampal lactate, myoinositol and phosphatidylcholines increase with aging.
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The biochemical connectivity between hippocampal metabolites decreases with aging.