Modulation of natural IgM autoantibodies to oxidative stress-related neo-epitopes on apoptotic cells in newborns of mothers with anti-Ro autoimmunity
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- 作者：Caroline Grö ; nwalla ; c ; 1 ; Robert M. Clancya ; 1 ; Lelise Getua ; Katy A. Lloydc ; Don L. Siegelb ; Joanne H. Reeda ; 2 ; Jill P. Buyona ; Gregg J. Silvermana ; gregg.silverman@nyumc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neonatal immunity ; Repertoire ; Neonatal lupus ; Maternal IgG ; Malondialdehyde
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：30-41
- 全文大小：2684 K
文摘
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Natural IgM binding of apoptosis-associated epitopes and Ro60 is common in neonates.
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Binding of cord IgM to apoptotic cells correlates with reactivity with malondialdehyde and is inhibitable by malondialdehyde-BSA.
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Newborns from IgG anti-Ro/La(+) mothers have higher IgM anti-Ro60 than other neonates.
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Newborns from IgG anti-Ro/La(+) mothers have lower IgM anti-MDA than other neonates.
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Maternal autoimmunity may influence the congenital IgM-repertoire of the newborn.