miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation

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• 作者：Maryaline Coffre¹ ; David Benhamou² ; David Rieß ; ³ ; ⁸ ; Lili Blumenberg¹ ; Valentina Snetkova¹ ; Marcus J. Hines¹ ; Tirtha Chakraborty³ ; ⁹ ; Sofia Bajwa¹ ; Kari Jensen³ ; Mark M.W. Chong⁴ ; ¹⁰ ; Lelise Getu⁵ ; Gregg J. Silverman¹ ; ⁵ ; Robert Blelloch⁶ ; Dan R. Littman⁴ ; ⁷ ; Dinis Calado³ ; ¹¹ ; Doron Melamed² ; Jane A. Skok¹ ; Klaus Rajewsky³ ; ¹² ; Sergei B. Koralov¹ ; ¹³ ; ^{sergei.koralov@nyumc.org}
• 关键词：B lymphocytes ; miRNA ; Dicer ; Drosha ; DGCR8 ; RAG ; PTEN ; PI3K/AKT ; B cell development ; receptor editing
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：22 November 2016
• 年：2016
• 卷：17
• 期：9
• 页码：2271-2285
• 全文大小：4431 K
• 卷排序：17

文摘

Dicer-/Drosha-/DGCR8-dependent ncRNAs are essential for pre-B survival and proliferation Dicer- and DGCR8-dependent miRNAs control the PI3K/AKT/FOXO1 pathway in B cells Regulation of PI3K signaling by miRNAs is essential for keeping Rag expression in check Loss of miRNAs in peripheral B cells leads to immunoglobulin light chain editing