The nucleus accumbens: a target for deep brain stimulation in obsessive–compulsive- and anxiety-disorders
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文摘
We considered clinical observations in patients with obsessive–compulsive- and anxiety-disorders, who underwent bilateral anterior capsulotomy, as well as anatomical and pathophysiological findings. Based on these considerations, we choose the shell region of the right nucleus accumbens as target for deep brain stimulation (DBS) in a pilot-series of four patients with severe obsessive–compulsive- and anxiety-disorders. Significant reduction in severity of symptoms has been achieved in three of four patients treated. Clinical results as well as a 15-O-H2O-PET study, perfomed in one patient during stimulation, speak in favour of the following hypothesis.

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