In acute promyelocytic leukemia (APL) low BAALC gene expression identifies a patient group with favorable overall survival and improved relapse free survival

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• 作者：Florian Nolte^a ; ^{florian.nolte@medma.uni-heidelberg.de} ; Anna Hecht^a ; Mark Reinwald^a ; Daniel Nowak^a ; Verena Nowak^a ; Benjamin Hanfstein^a ; Andreas Faldum^b ; Thomas Bü ; chner^c ; Karsten Spiekermann^d ; Cristina Sauerland^b ; Wolf-Karsten Hofmann^a ; Eva Lengfelder^a
• 关键词：Acute promyelocytic leukemia ; Prognosis ; BAALC ; Risk stratification ; Overall survival ; Relapse free survival
• 刊名：Leukemia Research
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：37
• 期：4
• 页码：378-382
• 全文大小：344 K

文摘

We evaluated the prognostic value of BAALC expression in 86 patients with acute promyelocytic leukemia (APL).

At 10 years, the overall survival (OS) was 66 % in all patients and 75 % in patients who achieved a complete remission (CR). Patients in the BAALC^low group showed an OS of 87 % as compared to 60 % in the BAALC^high group (p = 0.019). This difference was more pronounced in treatment responders (92 % vs. 70 % ; p = 0.035). In multivariate analyses low BAALC expression retained its prognostic relevance.

In conclusion, BAALC expression analysis might be useful in further risk stratification in APL patients.