Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study

详细信息    查看全文

• 作者：Flora H. Duits^a ; Pablo Martinez-Lage^b ; Claire Paquet^c ; ^d ; ^e ; Sebastiaan Engelborghs^f ; ^g ; Alberto Lleó ; ^h ; ⁱ ; Lucrezia Hausner^j ; José ; L. Molinuevo^k ; Erik Stomrud^l ; Lucia Farotti^m ; Inez H.G.B. Ramakersⁿ ; Magda Tsolaki^o ; Constance Skarsg&aring ; rd^p ; Ragnar &Aring ; strand^q ; Anders Wallin^r ; Martin Vyhnalek^s ; ^t ; Marie Holmber-Clausen^u ; Orestes V. Forlenza^v ; Laura Ghezzi^w ; Martin Ingelsson^x ; Erik I. Hoff^y ; Gerwin Roks^z ; Alexandre de Mendonç ; a^aa ; Janne M. Papma^ab ; Andrea Izagirre^b ; Mariko Taga^c ; ^d ; ^e ; Hanne Struyfs^f ; Daniel A. Alcolea^h ; ⁱ ; Lutz Frö ; lich^j ; Mircea Balasa^k ; Lennart Minthon^l ; Jos W.R. Twisk^ac ; Staffan Persson^ad ; Henrik Zetterberg^ad ; ^ae ; Wiesje M. van der Flier^a ; ^ac ; Charlotte E. Teunissen^af ; Philip Scheltens^a ; ¹ ; ^{p.scheltens@vumc.nl" class="auth_mail" title="E-mail the corresponding author} ; Kaj Blennow^ad ; ¹
• 关键词：Lumbar puncture ; Cognitive disorders ; Alzheimer's disease ; Memory clinic ; Post-LP complications ; Post-LP headache ; Multicenter study on LP feasibility
• 刊名：Alzheimer's & Dementia
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：12
• 期：2
• 页码：154-163
• 全文大小：820 K

文摘

Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations.

bsSec_2">Methods

bspara0015">We prospectively enrolled 3868 patients (50% women, age 66 ± 11 years, mini mental state examination 25 ± 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain.

bsSec_3">Results

bspara0020">A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect.

bsSec_4">Discussions

bspara0025">The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.