- 作者：Barbara J. Jefferis ; Peter Whincup ; Paul Welsh ; Goya Wannamethee ; Ann Rumley ; Lucy Lennon ; Andy Thomson ; Debbie Lawlor ; Claire Carson ; Shah Ebrahim ; Gordon Lowe
- 关键词：Myocardial infarction ; Stroke ; Inflammation ; Epidemiology ; MMP-9 ; Prospective ; Cohort
- 刊名：Atherosclerosis
- 出版年：2010
- 出版时间：February 2010
- 年：2010
- 卷：208
- 期：2
- 页码：557-563
- 全文大小：159 K
ObjectivesThe endopeptidase matrix metalloproteinase-9 (MMP-9) is implicated in atherosclerotic plaque rupture. We investigate prospective associations between MMP-9 and MI or stroke in an older general population cohort, accounting for established and novel cardiovascular risk factors.Methods
Baseline serum MMP-9 was measured in incident MI (n = 368) and stroke (n = 299) cases and two controls per case, ‘nested’ in prospective studies of 4252 men and 4286 women aged 60–79 years, sampled from General Practices in Britain in 1998–2000, with 7-year follow-up for fatal and non-fatal MI and stroke.
Results
Geometric mean MMP-9 was 528 ng/mL (IQR 397, 743) in MI cases compared to 501 ng/mL (IQR 370, 743) in controls, p = 0.10. Participants in the top compared to bottom third of MMP-9 levels had an age-adjusted odds ratio for MI of 1.53 (95 % CI 1.09, 2.13), which attenuated to 1.18 (95 % CI 0.81, 1.70) after adjustment for established and novel cardiovascular risk factors. There was weak evidence that OR differed according to pre-existing CVD; the OR for MI in 187 participants with pre-existing CVD was 2.20 (1.04, 4.64) and 1.24 (0.84, 1.82) in 715 participants without (LR test for interaction p = 0.06). Geometric mean MMP-9 levels were higher in stroke cases than controls; 522 ng/mL (IQR 363, 673) vs 487 (IQR 393, 704), p = 0.045; however adjustments similarly attenuated the associations.
Conclusions
While serum MMP-9 is univariately associated with risk of MI and stroke, it is not a strong independent risk marker for either.